SIK1B

Across TCGA cell cohorts, SIK1B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,401 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SIK1B-associated GO terms across cancer lineages are Cell-substrate junction assembly, Regulation of plasma membrane repair, and Regulation of miRNA metabolic process. Each is linked with SIK1B in more than 7 cancer types. Because this analysis shows association rather than direction, both SIK1B-to-partner and partner-to-SIK1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction assembly grouped by SIK1B-low versus SIK1B-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK1B→partner) and Y-score (partner→SIK1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cell-substrate junction assembly →	+0.126	+0.955	.001	.005	3	7
LARGE_INTESTINE	Regulation of plasma membrane repair →	+0.175	+1.121	.002	.001	3	7
LARGE_INTESTINE	Regulation of miRNA metabolic process →	+0.055	+1.110	<.001	<.001	3	7
PANCREAS	Regulation of canonical Wnt signaling pathway →	+0.056	+1.549	<.001	<.001	3	7
LARGE_INTESTINE	Cell-matrix adhesion →	+0.065	+1.044	.003	.001	3	7
CNS	Biological process involved in interaction with host →	+0.052	+0.939	.003	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,401 associations by consensus.

Cell-substrate junction assembly by SIK1B expression — LARGE_INTESTINE

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