SIK1B

Across TCGA pan-cancer cohorts, SIK1B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SIK1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SIK1B RNA is repressed in tumor relative to normal tissue. In most cancer types SIK1B is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.

KIRP, BRCA, and KIRC are the cancer types where SIK1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIK1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−1.884	<.001	9	view →
BRCA	All	All	−0.597	<.001	6	view →
KIRC	All	II,III,IV	−0.566	.008	6	view →
UCEC	All	All	−1.126	.001	4	view →
LUSC	Male	All	−0.940	<.001	4	view →
LIHC	All	All	−0.721	.003	3	view →
READ	All	III,IV	−1.714	.007	2	view →
PAAD	All	All	+1.037	.032	2	view →
LUAD	Female	All	−1.005	.001	2	view →
PRAD	All	All	−0.917	.001	2	view →
BLCA	Female	IV	−1.980	.031	1	view →
STAD	Female	III,IV	−0.610	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SIK1B–KIRP

Open the KIRP breakdown →