SIK1

Across TCGA patient cohorts, SIK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,646 significant associations in total. OV shows the largest number of these associations.

The most reproducible SIK1-associated GO terms across cancer lineages are Positive regulation of anoikis, Negative regulation of CREB transcription factor activity, and Response to corticotropin-releasing hormone. Each is linked with SIK1 in more than 29 cancer types. Because this analysis shows association rather than direction, both SIK1-to-partner and partner-to-SIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anoikis grouped by SIK1-low versus SIK1-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK1→partner) and Y-score (partner→SIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Positive regulation of anoikis →	-0.141	-1.628	<.001	<.001	3	30
LAML	Negative regulation of CREB transcription factor activity →	-0.075	-0.469	<.001	.004	2	15
MESO	Response to corticotropin-releasing hormone →	+0.134	+1.001	.002	.002	1	15
SCLC	Response to corticosteroid →	+0.061	+0.752	<.001	<.001	3	12
SCLC	Obsolete regulation of transcription from RNA polymerase II promoter in response to stress →	+0.107	+0.844	<.001	<.001	3	11
GBM	Response to fibroblast growth factor →	+0.022	+0.458	.001	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,646 associations by consensus.

Positive regulation of anoikis by SIK1 expression — UCS

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