SIK1

Across TCGA cell cohorts, SIK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,534 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SIK1-associated GO terms across cancer lineages are Positive regulation of anoikis, Regulation of intracellular protein transport, and Renal filtration cell differentiation. Each is linked with SIK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both SIK1-to-partner and partner-to-SIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anoikis grouped by SIK1-low versus SIK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK1→partner) and Y-score (partner→SIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anoikis →	-0.189	-1.606	<.001	<.001	2	12
OVARY	Regulation of intracellular protein transport →	+0.090	+2.242	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Renal filtration cell differentiation →	+0.229	+1.461	<.001	<.001	3	8
OESOPHAGUS	Glomerular epithelium development →	+0.220	+1.651	.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Podocyte differentiation →	+0.229	+1.461	<.001	<.001	3	8
OVARY	Assembly of actomyosin apparatus involved in cytokinesis →	+0.144	+1.568	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,534 associations by consensus.

Positive regulation of anoikis by SIK1 expression — BONE

Explore this box plot interactively →