SIK1

Across TCGA cell cohorts, SIK1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,958 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIK1-associated genes across cancer lineages are DHRS7B, PUM1, and GNB1. Each is linked with SIK1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SIK1-to-partner and partner-to-SIK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIK1 versus DHRS7B in PANCREAS, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK1→partner) and Y-score (partner→SIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DHRS7B →	+0.723	+0.763	.001	.007	3	7
BREAST	PUM1 →	-0.905	-1.196	.002	.001	3	6
URINARY_TRACT	GNB1 →	-0.714	-1.163	.008	.007	3	6
LUNG_SCLC	SRSF4 →	-0.581	-0.993	.003	.009	3	5
PANCREAS	STX2 →	-1.244	-1.076	<.001	<.001	3	5
PANCREAS	IKBIP →	-1.828	-1.007	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,958 associations by consensus.

SIK1 vs DHRS7B — PANCREAS

Explore this scatter interactively →