SIK1

Across TCGA cell cohorts, SIK1 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,389 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIK1-associated GO terms across cancer lineages are Clathrin coat disassembly, Positive regulation of triglyceride metabolic process, and Negative regulation of microtubule polymerization or depolymerization. Each is linked with SIK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIK1-to-partner and partner-to-SIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Clathrin coat disassembly grouped by SIK1-low versus SIK1-high in OESOPHAGUS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK1→partner) and Y-score (partner→SIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Clathrin coat disassembly →	+0.217	+1.172	.001	.004	3	5
BLOOD_Leukemia	Positive regulation of triglyceride metabolic process →	+0.122	+0.733	<.001	.003	3	5
LUNG_NSCLC_LUAD	Negative regulation of microtubule polymerization or depolymerization →	-0.073	-0.671	.006	.004	2	5
LUNG_NSCLC_LUAD	Synaptic transmission involved in micturition →	-0.119	-0.681	.006	.006	3	4
LARGE_INTESTINE	Regulation of homotypic cell-cell adhesion →	+0.109	+1.072	<.001	<.001	3	4
STOMACH	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	-0.095	-1.134	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,389 associations by consensus.

Clathrin coat disassembly by SIK1 expression — OESOPHAGUS

Explore this box plot interactively →