SIGLEC8

Across TCGA pan-cancer cohorts, SIGLEC8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SIGLEC8 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SIGLEC8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SIGLEC8 expression acts as an unfavorable survival marker.

LUSC, KIRC, and SKCM are the cancer types where SIGLEC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.223	0.749	<.001	24	view →
KIRC	DFS	Median	All	0.062	0.865	<.001	22	view →
SKCM	DFS	Median	All	0.374	0.627	.001	10	view →
LIHC	DFS	Median	All	0.150	0.557	.007	9	view →
PRAD	DFS	Median	All	0.594	0.886	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SIGLEC8–LUSC (OS)

Open the LUSC breakdown →