SIGLEC8

Across TCGA patient cohorts, SIGLEC8 protein abundance is significantly associated with the RNA expression of many other genes, with 3,729 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIGLEC8-associated genes across cancer lineages are POMT1, EGFR, and NOL9. Each is linked with SIGLEC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC8-to-partner and partner-to-SIGLEC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGLEC8 versus POMT1 in LUAD, with a Pearson correlation of -0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC8→partner) and Y-score (partner→SIGLEC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POMT1 →	-0.510	-0.378	.008	.009	3	2
GBM	EGFR →	-2.232	-0.594	<.001	<.001	3	2
LUAD	NOL9 →	-0.553	-0.470	.003	<.001	3	2
GBM	KIF1B →	-0.714	-0.678	.001	.003	3	2
GBM	TBC1D9 →	+0.815	+0.973	<.001	<.001	3	2
LSCC	HVCN1 →	+0.607	+0.751	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,729 associations by consensus.

SIGLEC8 vs POMT1 — LUAD

Explore this scatter interactively →