SIGLEC8

Across TCGA patient cohorts, SIGLEC8 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC8-associated genes across cancer lineages are PI3K-p110-a, Notch1, and p62 Lck ligand. Each is linked with SIGLEC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC8-to-partner and partner-to-SIGLEC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by SIGLEC8-low versus SIGLEC8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC8→partner) and Y-score (partner→SIGLEC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PI3K-p110-a →	-0.117	-2.450	.027	.020	3	2
UCEC	Notch1 →	+0.167	+2.424	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.340	+2.512	.002	.001	3	2
UCEC	PCNA →	+0.173	+2.070	.020	.001	3	2
SKCM	VHL →	-0.728	-3.321	.022	.009	3	2
UCEC	ATM →	-0.328	-1.700	.036	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PI3K-p110-a by SIGLEC8 expression — COAD

Explore this box plot interactively →