SIGLEC8

Across TCGA cell cohorts, SIGLEC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,689 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC8-associated GO terms across cancer lineages are Regulation of hepatocyte apoptotic process, Negative regulation of hepatocyte apoptotic process, and Positive regulation of actin filament depolymerization. Each is linked with SIGLEC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC8-to-partner and partner-to-SIGLEC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hepatocyte apoptotic process grouped by SIGLEC8-low versus SIGLEC8-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC8→partner) and Y-score (partner→SIGLEC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of hepatocyte apoptotic process →	+0.093	+0.622	<.001	<.001	3	3
BLOOD_Leukemia	Negative regulation of hepatocyte apoptotic process →	+0.093	+0.622	<.001	<.001	3	3
BLOOD_Leukemia	Positive regulation of actin filament depolymerization →	-0.088	-0.460	.001	.008	3	3
BLOOD_Leukemia	Late endosome to vacuole transport →	+0.075	+0.558	<.001	<.001	3	3
BLOOD_Leukemia	NADH dehydrogenase complex assembly →	+0.040	+0.445	.002	<.001	3	2
BLOOD_Leukemia	Regulation of collagen metabolic process →	+0.073	+0.452	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,689 associations by consensus.

Regulation of hepatocyte apoptotic process by SIGLEC8 expression — BLOOD_Leukemia

Explore this box plot interactively →