SIGLEC8

Across TCGA cell cohorts, SIGLEC8 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC8-associated genes across cancer lineages are WFDC8, CYP3A4, and OR2D3. Each is linked with SIGLEC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC8-to-partner and partner-to-SIGLEC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC8 grouped by SIGLEC8-low versus SIGLEC8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC8→partner) and Y-score (partner→SIGLEC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WFDC8 →	+0.145	+3.887	.006	.001	3	1
CNS	CYP3A4 →	+0.079	+3.479	.009	.009	3	1
CNS	OR2D3 →	+0.024	+3.730	.006	.002	3	1
CNS	TRIM40 →	+0.018	+4.058	<.001	<.001	3	1
CNS	TEX48 →	+0.213	+3.762	<.001	.004	3	1
CNS	SMIM28 →	+0.048	+4.321	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

WFDC8 by SIGLEC8 expression — CNS

Explore this box plot interactively →