SIGLEC5

Across TCGA cell cohorts, SIGLEC5 mutation is significantly associated with the RNA expression of many other genes, with 292 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC5-associated genes across cancer lineages are OR10Q1, BMP15, and TEX55. Each is linked with SIGLEC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC5-to-partner and partner-to-SIGLEC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Q1 grouped by SIGLEC5-low versus SIGLEC5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC5→partner) and Y-score (partner→SIGLEC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR10Q1 →	+0.167	+4.930	<.001	.008	3	1
BLOOD_Lymphoma	BMP15 →	+0.039	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TEX55 →	+0.055	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SPATA19 →	+0.307	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	IQCF5 →	+0.155	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	SIAH3 →	+0.024	+4.867	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 292 associations by consensus.

OR10Q1 by SIGLEC5 expression — SOFT_TISSUE

Explore this box plot interactively →