SIGLEC31P

Across TCGA pan-cancer cohorts, SIGLEC31P RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SIGLEC31P data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher SIGLEC31P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIGLEC31P expression acts as an unfavorable survival marker, although some lineages such as BLCA and LAML show a favorable association.

DLBC, BLCA, and THCA are the cancer types where SIGLEC31P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	III,IV	0.249	0.965	<.001	108	view →
BLCA	DFS	Tertile	III,IV	0.640	0.250	.001	45	view →
THCA	DFS	Tertile	II,III,IV	0.362	0.758	<.001	45	view →
UCS	OS	Tertile	All	0.242	0.622	.001	36	view →
UCEC	OS	Tertile	III,IV	0.734	0.843	.015	36	view →
OV	DFS	Tertile	IV	0.248	0.490	.015	18	view →
LGG	OS	Tertile	All	0.734	0.830	.009	15	view →
LAML	DFS	Quartile	All	0.721	0.519	.013	14	view →
STAD	OS	Quartile	II,III,IV	0.771	0.615	.024	10	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	9	view →
BRCA	DFS	Tertile	II,III,IV	0.887	0.945	.036	6	view →
ESCA	OS	Tertile	III,IV	0.596	0.334	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SIGLEC31P–DLBC (OS)

Open the DLBC breakdown →