Across TCGA patient cohorts, SIGLEC15 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC15-associated genes across cancer lineages are MEK1, STAT3_pY705, and C-Raf_pS338. Each is linked with SIGLEC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC15-to-partner and partner-to-SIGLEC15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC15→partner) and Y-score (partner→SIGLEC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.486	+3.000	.021	.037	3	1
UCEC	STAT3_pY705 →	-0.365	-3.000	.016	.037	3	1
UCEC	C-Raf_pS338 →	-0.108	-3.000	.022	.037	2	1
UCEC	Ku80 →	+0.346	+3.013	.011	.019	1	1
UCEC	Notch1 →	+0.228	+3.000	.005	.037	1	1
UCEC	Rab25 →	-0.439	-3.000	.022	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

SIGLEC15 survival (RNA) · tumor vs normal (RNA) · all SIGLEC15 data types