Across TCGA cell cohorts, SIGLEC15 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,344 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SIGLEC15-associated GO terms across cancer lineages are Regulation of muscle hypertrophy, Regulation of cardiac muscle hypertrophy, and Positive regulation of leukocyte migration. Each is linked with SIGLEC15 in more than 8 cancer types. Because this analysis shows association rather than direction, both SIGLEC15-to-partner and partner-to-SIGLEC15 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC15→partner) and Y-score (partner→SIGLEC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of muscle hypertrophy →	+0.116	+1.055	<.001	.004	3	9
BONE	Regulation of cardiac muscle hypertrophy →	+0.119	+1.055	<.001	.004	3	8
BONE	Positive regulation of leukocyte migration →	+0.116	+0.859	<.001	<.001	2	9
BONE	Actin filament depolymerization →	+0.191	+0.852	<.001	.009	3	8
SOFT_TISSUE	Steroid hormone secretion →	+1.259	+1.640	<.001	.002	3	8
SOFT_TISSUE	Eosinophil homeostasis →	+1.049	+1.410	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,344 associations by consensus.

Exploration

SIGLEC15 survival (RNA) · tumor vs normal (RNA) · all SIGLEC15 data types