Across TCGA cell cohorts, SIGLEC15 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC15-associated genes across cancer lineages are ITGAD, GSG1L2, and MMP27. Each is linked with SIGLEC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC15-to-partner and partner-to-SIGLEC15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC15→partner) and Y-score (partner→SIGLEC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.011	+3.510	<.001	.003	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	LALBA →	+0.038	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

SIGLEC15 survival (RNA) · tumor vs normal (RNA) · all SIGLEC15 data types