SIGLEC10

Across TCGA cell cohorts, SIGLEC10 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC10-associated genes across cancer lineages are SERPINB11, C4orf51, and SLC25A31. Each is linked with SIGLEC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC10-to-partner and partner-to-SIGLEC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINB11 grouped by SIGLEC10-low versus SIGLEC10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC10→partner) and Y-score (partner→SIGLEC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SERPINB11 →	+0.012	+2.967	.003	.003	3	2
URINARY_TRACT	C4orf51 →	+0.306	+5.087	<.001	.004	3	1
LUNG_SCLC	SLC25A31 →	+0.037	+3.847	<.001	.005	3	1
LUNG_SCLC	GYPB →	+0.153	+3.869	<.001	.002	3	1
SKIN	ASCL3 →	+0.061	+2.651	.002	.007	3	1
SKIN	POTEC →	+0.362	+3.256	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

SERPINB11 by SIGLEC10 expression — BLOOD_Leukemia

Explore this box plot interactively →