Across TCGA patient cohorts, SIGIRR RNA expression is significantly associated with the RNA expression of many other genes, with 17,695 significant associations in total. THYM shows the largest number of these associations.

The most reproducible SIGIRR-associated genes across cancer lineages are GSDMD, ZNF524, and STXBP2. Each is linked with SIGIRR in more than 29 cancer types. Because this analysis shows association rather than direction, both SIGIRR-to-partner and partner-to-SIGIRR results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGIRR→partner) and Y-score (partner→SIGIRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	GSDMD →	+1.168	+0.751	<.001	.001	3	30
LAML	ZNF524 →	+0.741	+0.769	<.001	<.001	3	29
UCS	STXBP2 →	+1.318	+1.510	<.001	<.001	3	29
ESCA	ADAP1 →	+2.073	+1.448	<.001	<.001	3	28
UCS	ANO9 →	+2.103	+2.140	<.001	<.001	3	28
UCS	UNC93B1 →	+1.051	+1.208	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,695 associations by consensus.

Exploration

SIGIRR survival (RNA) · tumor vs normal (RNA) · all SIGIRR data types