SIGIRR

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SIGIRR mutation is significantly associated with the RNA expression of many other genes, with 852 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGIRR-associated genes across cancer lineages are RNA5SP421, RNU6-345P, and RNU4ATAC5P. Each is linked with SIGIRR in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGIRR-to-partner and partner-to-SIGIRR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGIRR→partner) and Y-score (partner→SIGIRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADRNA5SP421 →+0.417+7.741<.001.00932
COADRNU6-345P →+0.352+7.741<.001.00932
COADRNU4ATAC5P →+0.436+7.741<.001.00932
LUADRNU6-326P →+0.293+7.930<.001.00832
LGGPGAM1P1 →+0.078+5.266<.001.00632
KIRPMIR4307 →+0.449+4.928<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 852 associations by consensus.

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