Across TCGA cell cohorts, SIGIRR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,039 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGIRR-associated GO terms across cancer lineages are Regulation of Toll signaling pathway, Flagellated sperm motility, and Sperm motility. Each is linked with SIGIRR in more than 9 cancer types. Because this analysis shows association rather than direction, both SIGIRR-to-partner and partner-to-SIGIRR results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGIRR→partner) and Y-score (partner→SIGIRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of Toll signaling pathway →	+0.174	+0.846	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.140	-1.622	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.140	-1.622	<.001	<.001	3	8
LARGE_INTESTINE	Regulation of membrane lipid distribution →	+0.057	+0.777	.006	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.137	-1.657	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.137	-1.657	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,039 associations by consensus.

Exploration

SIGIRR survival (RNA) · tumor vs normal (RNA) · all SIGIRR data types