Across TCGA cell cohorts, SIGIRR mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGIRR-associated genes across cancer lineages are KCNA4, PPP1R17, and GKN1. Each is linked with SIGIRR in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGIRR-to-partner and partner-to-SIGIRR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGIRR→partner) and Y-score (partner→SIGIRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNA4 →	+0.028	+4.922	<.001	.009	3	1
LARGE_INTESTINE	PPP1R17 →	+0.108	+4.467	<.001	.004	3	1
LARGE_INTESTINE	GKN1 →	+0.066	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

SIGIRR survival (RNA) · tumor vs normal (RNA) · all SIGIRR data types