SIDT1

Across TCGA patient cohorts, SIDT1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIDT1-associated genes across cancer lineages are PKC-delta_pS664, ASNS, and 4E-BP1. Each is linked with SIDT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIDT1-to-partner and partner-to-SIDT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by SIDT1-low versus SIDT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIDT1→partner) and Y-score (partner→SIDT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.091	-2.415	.016	.002	3	3
UCEC	ASNS →	+0.421	+1.584	<.001	.005	3	3
UCEC	4E-BP1 →	+0.351	+1.955	<.001	.002	3	3
UCEC	Cyclin-E2 →	+0.173	+1.857	.001	.004	3	3
UCEC	eIF4E →	+0.151	+1.584	.022	.005	3	2
UCEC	FoxM1 →	+0.290	+1.836	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PKC-delta_pS664 by SIDT1 expression — UCEC

Explore this box plot interactively →