SIDT1

Across TCGA pan-cancer cohorts, SIDT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SIDT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SIDT1 RNA is repressed in tumor relative to normal tissue. In most cancer types SIDT1 is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRP, BRCA, and COAD are the cancer types where SIDT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIDT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.763	<.001	11	view →
BRCA	All	III,IV	+1.123	<.001	6	view →
COAD	Female	All	−0.980	<.001	6	view →
LUAD	Female	All	+0.776	<.001	6	view →
KIRC	All	III,IV	−0.327	.005	6	view →
LUSC	Male	II,III,IV	−0.949	<.001	5	view →
READ	All	II,III,IV	−1.122	.004	4	view →
HNSC	All	II,III,IV	−0.479	.008	4	view →
KICH	Male	II,III,IV	−0.737	.008	2	view →
LUAD	All	IV	−0.549	.041	2	view →
STAD	All	All	+0.509	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

SIDT1–KIRP

Open the KIRP breakdown →