SIDT1

Across TCGA cell cohorts, SIDT1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIDT1-associated genes across cancer lineages are PYDC2, SOX14, and NLRP8. Each is linked with SIDT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIDT1-to-partner and partner-to-SIDT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC2 grouped by SIDT1-low versus SIDT1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIDT1→partner) and Y-score (partner→SIDT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PYDC2 →	+0.152	+4.643	<.001	.004	3	2
BLOOD_Leukemia	SOX14 →	+0.004	+3.684	<.001	.004	3	2
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	PPIAL4F →	+0.060	+4.906	<.001	.006	3	1
BLOOD_Myeloma	TAAR6 →	+0.043	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PYDC2 by SIDT1 expression — LUNG_SCLC

Explore this box plot interactively →