SIAH2

Across TCGA patient cohorts, SIAH2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,443 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIAH2-associated proteins across cancer lineages are GMPS, ACAA2, and PCYT1A. Each is linked with SIAH2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIAH2-to-partner and partner-to-SIAH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIAH2 versus GMPS in LSCC, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH2→partner) and Y-score (partner→SIAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GMPS →	+0.581	+1.077	<.001	<.001	3	6
UCEC	ACAA2 →	-0.706	-0.812	<.001	<.001	3	5
LSCC	PCYT1A →	+0.581	+1.031	<.001	<.001	3	5
LSCC	RFC4 →	+0.507	+0.938	<.001	<.001	3	5
LSCC	RUVBL1 →	+0.248	+0.878	<.001	<.001	3	5
LUAD	MCM6_S762 →	+1.213	+0.392	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,443 associations by consensus.

SIAH2 vs GMPS — LSCC

Explore this scatter interactively →