SIAE

Across TCGA patient cohorts, SIAE RNA expression is significantly associated with the protein abundance of many other proteins, with 14,537 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SIAE-associated proteins across cancer lineages are ARHGEF12, SGSM3, and ACAD8. Each is linked with SIAE in more than 5 cancer types. Because this analysis shows association rather than direction, both SIAE-to-partner and partner-to-SIAE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIAE versus ARHGEF12 in BRCA, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAE→partner) and Y-score (partner→SIAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF12 →	+0.348	+1.062	<.001	<.001	3	6
BRCA	SGSM3 →	+0.457	+0.874	<.001	<.001	3	6
OV	ACAD8 →	+0.458	+0.808	<.001	<.001	3	6
LUAD	TOP2A_S1106 →	-1.075	-0.727	<.001	<.001	3	5
LUAD	TOP2A_S1525 →	-0.971	-0.744	<.001	<.001	3	5
HNSC	PIGR →	+0.888	+0.483	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,537 associations by consensus.

SIAE vs ARHGEF12 — BRCA

Explore this scatter interactively →