SIAE

Across TCGA cell cohorts, SIAE mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SIAE-associated genes across cancer lineages are CES5A, C14orf180, and CLLU1-AS1. Each is linked with SIAE in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAE-to-partner and partner-to-SIAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CES5A grouped by SIAE-low versus SIAE-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAE→partner) and Y-score (partner→SIAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CES5A →	+0.012	+4.087	<.001	.009	3	1
URINARY_TRACT	C14orf180 →	+0.292	+4.087	.002	.009	3	1
URINARY_TRACT	CLLU1-AS1 →	+0.085	+4.087	<.001	.009	3	1
URINARY_TRACT	CT45A6 →	+0.027	+4.087	<.001	.009	3	1
URINARY_TRACT	CFAP97D2 →	+0.032	+4.087	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CES5A by SIAE expression — URINARY_TRACT

Explore this box plot interactively →