SI

Across TCGA pan-cancer cohorts, SI Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated SI data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SI Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SI expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, KICH, and LIHC are the cancer types where SI Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.918	0.292	<.001	36	view →
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
LIHC	DFS	Median	II,III,IV	0.089	0.435	<.001	18	view →
STAD	OS	Median	II,III,IV	0.833	0.396	.022	17	view →
HNSC	OS	Median	IV	0.298	0.657	.011	9	view →
PRAD	DFS	Median	All	0.412	0.776	.003	6	view →
BRCA	OS	Median	III,IV	0.207	0.833	<.001	6	view →
LUSC	OS	Median	II,III,IV	0.612	0.745	.034	6	view →
ESCA	OS	Median	All	0.281	0.546	.008	5	view →
SCLC	OS	Median	II,III,IV	0.303	0.551	.031	5	view →
SKCM	OS	Median	All	0.928	0.858	.032	4	view →
SARC	DFS	Median	All	0.166	0.517	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SI–UCEC (DFS)

Open the UCEC breakdown →