SI

Across TCGA pan-cancer cohorts, SI RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SI’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SI RNA is repressed in tumor relative to normal tissue. In most cancer types SI is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and THCA are the cancer types where SI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−3.170	<.001	9	view →
READ	All	II,III,IV	−4.054	.003	4	view →
THCA	All	All	−0.008	.002	2	view →
KIRC	Female	II,III,IV	+0.003	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SI–COAD

Open the COAD breakdown →