SI

Across TCGA pan-cancer cohorts, SI mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SI data layer compared with 20 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SI mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SI expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC are the cancer types where SI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.607	0.378	.006	20	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

SI–PDAC (OS)

Open the PDAC breakdown →