SI

Across TCGA cell cohorts, SI mutation is significantly associated with the RNA expression of many other genes, with 1,337 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SI-associated genes across cancer lineages are MAPK8IP2, ABHD12, and COX10. Each is linked with SI in more than 2 cancer types. Because this analysis shows association rather than direction, both SI-to-partner and partner-to-SI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK8IP2 grouped by SI-low versus SI-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SI→partner) and Y-score (partner→SI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MAPK8IP2 →	+0.498	+3.070	.002	.008	3	3
LUNG_NSCLC_LUAD	ABHD12 →	-0.621	-2.807	.001	<.001	3	3
LARGE_INTESTINE	COX10 →	+0.605	+3.321	<.001	.002	3	3
BLOOD_Myeloma	MAJIN →	+0.106	+3.781	.003	.002	3	2
BLOOD_Myeloma	ZNF483 →	+0.336	+3.321	<.001	.007	3	2
OESOPHAGUS	CRYBB3 →	+0.357	+3.447	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,337 associations by consensus.

MAPK8IP2 by SI expression — BLOOD_Lymphoma

Explore this box plot interactively →