Across TCGA patient cohorts, SHTN1 mutation is significantly associated with the RNA expression of many other genes, with 2,983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHTN1-associated genes across cancer lineages are RNU1-84P, RNU4ATAC5P, and RNU2-47P. Each is linked with SHTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHTN1-to-partner and partner-to-SHTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHTN1→partner) and Y-score (partner→SHTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU1-84P →	+0.455	+4.788	<.001	.006	3	4
HNSC	RNU4ATAC5P →	+0.265	+4.505	<.001	.009	3	3
STAD	RNU2-47P →	+0.612	+5.366	<.001	.005	3	3
STAD	RNA5SP326 →	+0.596	+5.026	<.001	.009	3	3
UCEC	RNA5SP411 →	+0.743	+1.461	<.001	.009	3	2
HNSC	TAS2R16 →	+0.036	+4.505	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,983 associations by consensus.

Exploration

SHTN1 survival (RNA) · tumor vs normal (RNA) · all SHTN1 data types