SHROOM4

Across TCGA pan-cancer cohorts, SHROOM4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SHROOM4 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SHROOM4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHROOM4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where SHROOM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.520	0.887	.002	22	view →
LUAD	DFS	Tertile	III,IV	0.379	0.993	.001	19	view →
CCRCC	OS	Tertile	All	1.000	0.600	.019	15	view →
PDAC	DFS	Tertile	III,IV	0.554	0.955	.013	8	view →
GBM	DFS	Tertile	All	0.248	0.423	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SHROOM4–LSCC (DFS)

Open the LSCC breakdown →