SHROOM4

Across TCGA patient cohorts, SHROOM4 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,277 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SHROOM4-associated proteins across cancer lineages are SHROOM4_S299, PRKG1, and SEPTIN4. Each is linked with SHROOM4 in more than 8 cancer types. Because this analysis shows association rather than direction, both SHROOM4-to-partner and partner-to-SHROOM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHROOM4 versus SHROOM4_S299 in LSCC, with a Pearson correlation of 0.61.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM4→partner) and Y-score (partner→SHROOM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SHROOM4_S299 →	+0.780	+0.849	<.001	<.001	3	9
OV	PRKG1 →	+0.679	+0.740	.001	<.001	3	9
GBM	SEPTIN4 →	+0.563	+0.452	<.001	<.001	3	8
CCRCC	SEPTIN7 →	+0.225	+0.590	<.001	<.001	3	8
HNSC	SHROOM4_S282 →	+0.805	+0.880	<.001	<.001	3	8
BRCA	FERMT2 →	+0.678	+0.825	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,277 associations by consensus.

SHROOM4 vs SHROOM4_S299 — LSCC

Explore this scatter interactively →