SHROOM4

Across TCGA patient cohorts, SHROOM4 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHROOM4-associated genes across cancer lineages are eEF2, PCNA, and MIG-6. Each is linked with SHROOM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHROOM4-to-partner and partner-to-SHROOM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SHROOM4-low versus SHROOM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM4→partner) and Y-score (partner→SHROOM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.291	+1.765	.002	.011	3	3
UCEC	PCNA →	+0.173	+2.058	.002	<.001	3	3
SKCM	MIG-6 →	+0.117	+1.725	.030	.024	3	3
UCEC	GAPDH →	+0.424	+2.169	.002	.002	3	2
STAD	PDK1_pS241 →	+0.212	+2.828	.011	.033	3	2
STAD	Src_pY527 →	-0.559	-3.169	.021	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

eEF2 by SHROOM4 expression — UCEC

Explore this box plot interactively →