SHROOM4

Across TCGA cell cohorts, SHROOM4 mutation is significantly associated with the mutation status of many other genes, with 3,469 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHROOM4-associated genes across cancer lineages are USP35, SPAG17, and HDAC9. Each is linked with SHROOM4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SHROOM4-to-partner and partner-to-SHROOM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP35 grouped by SHROOM4-low versus SHROOM4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM4→partner) and Y-score (partner→SHROOM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP35 →	+4.303	+4.000	.001	.001	1	6
OVARY	SPAG17 →	+3.047	+4.510	.001	.001	1	5
OVARY	HDAC9 →	+4.217	+4.217	.001	.001	1	5
OVARY	LIMCH1 →	+3.632	+3.930	.003	.003	1	5
OVARY	HECW2 →	+3.632	+3.930	.003	.003	1	5
BLOOD_Leukemia	CDH24 →	+3.145	+3.932	.004	.004	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,469 associations by consensus.

USP35 by SHROOM4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →