SHROOM3

Across TCGA cell cohorts, SHROOM3 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHROOM3-associated genes across cancer lineages are SPAM1, OR5H6, and C12orf57. Each is linked with SHROOM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHROOM3-to-partner and partner-to-SHROOM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAM1 grouped by SHROOM3-low versus SHROOM3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM3→partner) and Y-score (partner→SHROOM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPAM1 →	+0.019	+4.369	<.001	.008	3	2
SOFT_TISSUE	OR5H6 →	+0.016	+4.369	<.001	.008	3	2
LARGE_INTESTINE	C12orf57 →	+0.751	+1.850	.001	.006	3	2
LARGE_INTESTINE	BEND3 →	+0.449	+1.936	.009	.005	3	2
LARGE_INTESTINE	MICB →	+1.042	+3.459	.003	.001	3	2
URINARY_TRACT	MYL7 →	+0.750	+3.237	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

SPAM1 by SHROOM3 expression — SOFT_TISSUE

Explore this box plot interactively →