SHROOM3-AS1

Across TCGA pan-cancer cohorts, SHROOM3-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SHROOM3-AS1 data layer.

The strongest signal is observed in thymoma (THYM), where higher SHROOM3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SHROOM3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and MESO show a favorable association.

THYM, KIRC, and ACC are the cancer types where SHROOM3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.871	0.990	<.001	65	view →
KIRC	DFS	Median	IV	0.359	0.608	.001	65	view →
ACC	OS	Quartile	III,IV	0.110	0.628	<.001	51	view →
BRCA	DFS	Tertile	III,IV	0.947	0.794	.001	47	view →
PAAD	DFS	Quartile	All	0.192	0.459	.001	39	view →
LUSC	OS	Median	All	0.587	0.722	.002	32	view →
LIHC	DFS	Tertile	All	0.216	0.331	<.001	31	view →
MESO	DFS	Median	All	0.476	0.306	.007	28	view →
UCEC	OS	Median	All	0.902	0.946	.021	28	view →
UVM	DFS	Tertile	All	0.440	0.786	.032	27	view →
UCS	DFS	Median	IV	0.885	0.440	.015	18	view →
THCA	OS	Quartile	II,III,IV	0.701	0.982	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SHROOM3-AS1–THYM (OS)

Open the THYM breakdown →