SHROOM3-AS1

Across TCGA pan-cancer cohorts, SHROOM3-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SHROOM3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SHROOM3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SHROOM3-AS1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, STAD, and LUSC are the cancer types where SHROOM3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHROOM3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.241	<.001	9	view →
STAD	Male	All	+0.511	<.001	6	view →
LUSC	Male	II,III,IV	−0.341	<.001	6	view →
UCEC	All	All	−0.386	<.001	4	view →
CHOL	All	All	+0.446	.013	2	view →
KICH	All	All	−0.189	.009	1	view →
KIRP	All	All	−0.183	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SHROOM3-AS1–KIRC

Open the KIRC breakdown →