SHROOM2

Across TCGA patient cohorts, SHROOM2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,166 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHROOM2-associated genes across cancer lineages are GPR143, IGFBP2, and DLG3. Each is linked with SHROOM2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SHROOM2-to-partner and partner-to-SHROOM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHROOM2 versus GPR143 in COAD, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM2→partner) and Y-score (partner→SHROOM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPR143 →	+2.051	+0.922	<.001	.002	3	9
GBM	IGFBP2 →	+1.496	+0.563	<.001	<.001	3	6
BRCA	DLG3 →	+0.697	+0.471	<.001	<.001	3	5
GBM	LNX1 →	+0.924	+0.403	<.001	<.001	3	5
GBM	CLDN34 →	+0.520	+0.534	<.001	<.001	3	5
LSCC	PUDP →	+0.599	+0.385	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,166 associations by consensus.

SHROOM2 vs GPR143 — COAD

Explore this scatter interactively →