SHQ1

Across TCGA pan-cancer cohorts, SHQ1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SHQ1 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SHQ1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHQ1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, LUAD, and BLCA are the cancer types where SHQ1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.022	0.844	<.001	48	view →
LUAD	OS	Median	All	0.158	0.835	<.001	18	view →
BLCA	OS	Median	IV	0.153	0.599	.018	9	view →
LIHC	DFS	Median	II,III,IV	0.099	0.429	.012	6	view →
SKCM	OS	Median	II,III,IV	0.245	0.731	.014	6	view →
UCEC	DFS	Median	All	1.000	0.631	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SHQ1–OV (OS)

Open the OV breakdown →