SHQ1

Across TCGA pan-cancer cohorts, SHQ1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SHQ1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SHQ1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHQ1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

OV, PDAC, and HNSC are the cancer types where SHQ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.202	1.000	.038	8	view →
PDAC	DFS	Median	II,III,IV	0.894	0.444	.011	5	view →
HNSC	OS	Median	All	0.708	0.953	.016	5	view →
UCEC	DFS	Median	All	0.726	0.956	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SHQ1–OV (DFS)

Open the OV breakdown →