SHPRH

Across TCGA pan-cancer cohorts, SHPRH mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SHPRH data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SHPRH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHPRH expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where SHPRH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.463	0.823	.028	12	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	10	view →
PDAC	DFS	Quartile	II,III,IV	0.545	0.265	.038	2	view →
CCRCC	DFS	Median	All	0.936	0.594	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SHPRH–HNSC (DFS)

Open the HNSC breakdown →