SHPRH

Across TCGA pan-cancer cohorts, SHPRH RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SHPRH’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SHPRH RNA is repressed in tumor relative to normal tissue. In most cancer types SHPRH is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where SHPRH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHPRH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−1.204	<.001	10	view →
KICH	Female	All	−0.965	<.001	6	view →
BRCA	All	III,IV	−0.708	<.001	6	view →
CHOL	All	All	+0.800	.002	4	view →
KIRC	Male	II,III,IV	−0.315	.018	4	view →
UCEC	All	All	−0.558	.002	2	view →
LUSC	All	All	+0.243	.013	2	view →
KIRP	Male	All	−0.404	.008	1	view →
LIHC	All	All	+0.148	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SHPRH–THCA

Open the THCA breakdown →