SHPRH

Across TCGA patient cohorts, SHPRH mutation is significantly associated with the RNA expression of many other genes, with 4,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHPRH-associated genes across cancer lineages are ADAM32, LINC01072, and VRK1. Each is linked with SHPRH in more than 2 cancer types. Because this analysis shows association rather than direction, both SHPRH-to-partner and partner-to-SHPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM32 grouped by SHPRH-low versus SHPRH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHPRH→partner) and Y-score (partner→SHPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADAM32 →	-0.358	-1.681	<.001	<.001	3	3
UCEC	LINC01072 →	+0.057	+1.319	.009	.008	3	3
UCEC	VRK1 →	+0.367	+1.708	.004	.001	3	3
UCEC	VAPA →	+0.266	+1.060	.003	.006	3	3
LUSC	CPLX1 →	+0.853	+3.506	<.001	.002	3	3
COAD	VANGL2 →	-1.415	-3.700	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,949 associations by consensus.

ADAM32 by SHPRH expression — UCEC

Explore this box plot interactively →