SHPRH

Across TCGA patient cohorts, SHPRH mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHPRH-associated genes across cancer lineages are NF2, beta-Catenin, and MIG-6. Each is linked with SHPRH in more than 3 cancer types. Because this analysis shows association rather than direction, both SHPRH-to-partner and partner-to-SHPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by SHPRH-low versus SHPRH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHPRH→partner) and Y-score (partner→SHPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NF2 →	+0.185	+2.467	.028	.011	3	4
LUSC	beta-Catenin →	+0.723	+3.335	.001	.005	3	3
LUAD	MIG-6 →	+0.262	+3.169	.012	.019	3	3
UCEC	Ku80 →	+0.187	+1.483	.003	.003	3	3
UCEC	PDCD4 →	-0.388	-1.192	.002	.007	3	3
UCEC	Caspase-7-cleavedD198 →	+0.701	+1.912	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

NF2 by SHPRH expression — COAD

Explore this box plot interactively →