SHPRH

Across TCGA cell cohorts, SHPRH mutation is significantly associated with the RNA expression of many other genes, with 879 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHPRH-associated genes across cancer lineages are TIMD4, S100G, and DPH5. Each is linked with SHPRH in more than 1 cancer types. Because this analysis shows association rather than direction, both SHPRH-to-partner and partner-to-SHPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMD4 grouped by SHPRH-low versus SHPRH-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHPRH→partner) and Y-score (partner→SHPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TIMD4 →	+0.857	+2.987	.001	.001	3	2
OVARY	S100G →	+0.384	+3.095	<.001	<.001	3	2
LARGE_INTESTINE	DPH5 →	+0.576	+3.459	<.001	.001	3	2
LARGE_INTESTINE	NQO2 →	+0.738	+2.364	.008	<.001	3	2
LARGE_INTESTINE	STRA6 →	-1.313	-2.278	.004	.001	3	2
LARGE_INTESTINE	COA7 →	+0.543	+2.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 879 associations by consensus.

TIMD4 by SHPRH expression — OVARY

Explore this box plot interactively →