Across TCGA patient cohorts, SHOX mutation is significantly associated with the RNA expression of many other genes, with 1,565 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SHOX-associated genes across cancer lineages are CENPU, FXN, and NCAPH2. Each is linked with SHOX in more than 2 cancer types. Because this analysis shows association rather than direction, both SHOX-to-partner and partner-to-SHOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOX→partner) and Y-score (partner→SHOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.676	+4.119	.005	<.001	3	3
UCEC	FXN →	+0.417	+3.010	.005	<.001	3	3
UCEC	NCAPH2 →	+0.498	+4.087	.001	<.001	3	3
COAD	RNA5SP477 →	+0.877	+2.688	<.001	.003	3	3
UCEC	ACD →	+0.736	+4.119	<.001	<.001	3	3
UCEC	CSK →	+0.382	+2.332	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,565 associations by consensus.

Exploration

SHOX survival (RNA) · tumor vs normal (RNA) · all SHOX data types