Across TCGA patient cohorts, SHOX mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHOX-associated genes across cancer lineages are PCNA, eIF4E, and Cyclin-B1. Each is linked with SHOX in more than 3 cancer types. Because this analysis shows association rather than direction, both SHOX-to-partner and partner-to-SHOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOX→partner) and Y-score (partner→SHOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.364	+3.182	.001	.009	3	4
UCEC	eIF4E →	+0.201	+3.013	.029	.018	3	3
UCEC	Cyclin-B1 →	+0.659	+3.321	.007	.010	3	3
UCEC	EGFR_pY1068 →	-0.254	-2.807	.020	.003	3	2
UCEC	Ku80 →	+0.300	+2.331	.003	.019	3	2
UCEC	PDCD4 →	-0.467	-2.312	.023	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

SHOX survival (RNA) · tumor vs normal (RNA) · all SHOX data types