Across TCGA cell cohorts, SHOX RNA expression is significantly associated with the go_rna of many other GO terms, with 219 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SHOX-associated GO terms across cancer lineages are Sex differentiation, Regulation of nuclear receptor-mediated glucocorticoid signaling pathway, and Locomotor rhythm. Each is linked with SHOX in more than 2 cancer types. Because this analysis shows association rather than direction, both SHOX-to-partner and partner-to-SHOX results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOX→partner) and Y-score (partner→SHOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Sex differentiation →	-0.063	-0.005	.001	.008	3	2
LUNG_NSCLC_LUAD	Regulation of nuclear receptor-mediated glucocorticoid signaling pathway →	+0.087	+0.008	.009	.006	3	2
SOFT_TISSUE	Locomotor rhythm →	+0.145	+0.764	<.001	.009	2	3
SOFT_TISSUE	Positive regulation of developmental pigmentation →	-0.076	-0.806	.001	.002	3	2
SOFT_TISSUE	Lens fiber cell morphogenesis →	+0.160	+0.812	<.001	.002	3	2
OESOPHAGUS	Cellular response to catecholamine stimulus →	+0.089	+0.020	.009	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 219 associations by consensus.

Exploration

SHOX survival (RNA) · tumor vs normal (RNA) · all SHOX data types